Thermodynamics of Enzyme-Catalysed Reactions

Since the pH is treated as an independent variable in biochemical thermodynamics, the Gibbs energy G does not provide the criterion for equilibrium, but the transformed Gibbs energy G’ does. The standard transformed Gibbs energy of formation DfG’ of a reactant (sum of species) can be calculated at the desired temperature, pH, and ionic strength if the standard Gibbs energies of formation DfG and standard entropies of formation DfH of the species that make up the reactant are known. BasicBiochemData3 in MathSource provides species properties for 199 biochemical reactants and Mathematica programs for calculating apparent equilibrium constants K’ and other transformed thermodynamic properties of enzyme-catalysed reactions are given. This database can be extended, and the number of reactions for which apparent equilibrium constants can be calculated increases exponentially with the number of reactants in the database. 1 http://www.beilstein-institut.de/escec2006/proceedings/Alberty/Alberty.pdf ESCEC, March 19 – 23, 2006, R desheim/Rhein, Germany Beilstein-Institut